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Molecular Genetics of Inflammatory Bowel Disease

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 							Molecular Genetics of Inflammatory Bowel Disease
  Editors: D'Amato, Mauro, Rioux, John D
 

  343 pages | PDF | 2013
  Springer
  
  Research in Crohn’s disease (CD) and ulcerative colitis (UC), together known as the inflammatory bowel
diseases (IBD), has truly seen a revolution in the last 5-10 years. This book examines how these genetic discoveries
have led to the identification of biological functions not previously associated with IBD pathophysiology (e.g.
autophagy), how multiple genetic risk factors for IBD converge on given biological functions and that together the
identified variants in these genes have predisposing and protective roles (e.g. the multiple variants in the receptor
for the IL23 cytokine and its signaling cascade), and how having such a large number of known genetic risk factors has
changed our understanding not only about the genetic and molecular overlap between CD and UC, but also between these
diseases and other chronic inflammatory diseases (e.g. psoriasis, multiple sclerosis, type 1 diabetes and many
others).
   						

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